Is chlorhexidine mouth rinse, used as a mono-therapy or adjunct with oral hygiene, effective at reducing plaque growth and gingival inflammation?

摘要

This study describes a systematic review of the best available evidence on the effectiveness ofa chlorhexidine mouth rinse as a mono-therapy or as an adjunct to mechanical oral hygieneagainst plaque growth and gingival inflammation. Medline, EMBASE and the CochraneCentral register of Controlled Trials were searched up to April 2011. Randomised controlledclinical trials that compared chlorhexidine to placebo or controlled mouth rinses or regularoral hygiene for a minimum duration of at least four weeks amongst gingivitis patients(≥ 18 years of age) were included. A total of 30 publications fulfilled the selection criteria.Clinical parameters measured at baseline and end of trial were plaque, gingival inflammation,bleeding and staining. Chlorhexidine reduced plaque by 33% and gingivitis by 26% comparedto a placebo or a control mouth rinse. The investigators concluded that when used togetherwith oral hygiene, chlorhexidine mouth rinses provide significant reductions in plaque andgingivitis scores in gingivitis patients, but a significant increase in staining compared toplacebo or control mouth rinses.